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Nanoparticle that Mimics Salmonella Counteracts Chemotherapy Resistance

| August 22, 2016 | 0 Comments

Nanoparticle that Mimics Salmonella Counteracts Chemotherapy Resistance Researchers at the University of Massachusetts Medical School have designed a nanoparticle that mimics the bacterium Salmonella and may help to counteract a major mechanism of chemotherapy resistance.Working with mouse models of colon and breast cancer, Beth McCormick, Ph.D., and her colleagues demonstrated that when combined with chemotherapy, […]

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Targeted Therapies, Tooth Extraction, and Metastasis

| August 14, 2016 | 0 Comments

Targeted Therapies, Tooth Extraction, and Metastasis Oncogenic mutations in RAS pathway genes such as BRAF and NRAS play a significant role in melanoma, and patients with the BRAFV600E mutation often show impressive responses to targeted therapies. Usually, however, such responses are short-lived due to the rise of resistant clones. Obenauf, Rosen, Massague, and colleagues have […]

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Grantee Spotlight: Kimberly Payne, Ph.D. – Investigating Leukemia Health Disparities in Hispanic and Native American Children

| August 14, 2016 | 0 Comments

Grantee Spotlight: Kimberly Payne, Ph.D. – Investigating Leukemia Health Disparities in Hispanic and Native American Children Acute Lymphoblastic Leukemia (ALL), cancer of the blood and bone marrow, is the most common childhood malignancy, representing about 25% of cancer diagnoses among children younger than 15 years. Although it is highly treatable when detected early, Hispanic and […]

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Special Spotlight: Asian American and Pacific Islander Heritage Month

| August 13, 2016 | 0 Comments

Special Spotlight: Asian American and Pacific Islander Heritage Month CRCHD joins the rest of the nation in honoring AAPI Heritage Month in May. AAPIs have the highest incidence of both liver and stomach cancers, and are twice as likely as whites to die from these cancers. May is also designated as Melanoma/Skin Cancer Prevention and […]

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President Obama’s Budget Request Affirms Commitment to Progress against Cancer

| August 13, 2016 | 0 Comments

President Obama’s Budget Request Affirms Commitment to Progress against Cancer Yesterday, the White House released the President’s fiscal year (FY) 2017 Budget Request, which includes $680 million of additional funding for NCI to support the cancer research initiative inspired by Vice President Biden.The budget request affirms the administration’s commitment to cancer research and the realistic […]

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Report Offers Comprehensive Look at Global Smokeless Tobacco Use

| August 13, 2016 | 0 Comments

Report Offers Comprehensive Look at Global Smokeless Tobacco Use For more than half a century, following the 1964 report of the Surgeon General, Smoking and Health, scientific research and global tobacco control efforts have been directed against cigarette smoking. But in some parts of the world, other forms of tobacco, including many forms of smokeless […]

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Using Gene Expression to Diagnose Lung Cancer More Accurately

| August 12, 2016 | 0 Comments

Using Gene Expression to Diagnose Lung Cancer More Accurately Assessing gene expression in normal cells from the upper airways of current and former smokers with suspected lung cancer may be useful in improving the diagnostic accuracy of bronchoscopy, potentially reducing the need for invasive biopsies, according to a new study published in the New England […]

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The Cancer Genome Atlas: Generating a “Parts List” for Cancer

| August 12, 2016 | 0 Comments

The Cancer Genome Atlas: Generating a “Parts List” for Cancer When I was working in a genomics laboratory in the 1990s, I sequenced a section of human chromosome 7. The part I focused on coded for a tumor-suppressor gene. At that time, we had to read the DNA sequence letter by letter in short stretches […]

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Cancer Trends: Influencing Care and Research Priorities

| August 11, 2016 | 0 Comments

Cancer Trends: Influencing Care and Research Priorities The following is the first in a series of posts from senior NCI scientists and leaders on NCI’s Annual Plan and Budget Proposal for Fiscal Year 2017, which was officially submitted to the President on September 17, 2015. The proposal provides an overview of NCI’s priorities and key […]

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Nanoparticle Delivers Cancer Drugs to Tumor Blood Vessels

| August 1, 2016 | 0 Comments

Nanoparticle Delivers Cancer Drugs to Tumor Blood Vessels In a set of studies in mice bearing human tumors, nanoparticles designed to bind to a protein called P-selectin successfully delivered both chemotherapy drugs and targeted therapies to tumor blood vessels. Targeting the blood vessels improved the delivery of drugs to tumor tissue, causing the tumors to […]

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